SOME BIOLOGICAL PROPERTIES OF MYCOPHENOLIC ACID
نویسندگان
چکیده
منابع مشابه
Some biological properties of mycophenolic acid.
Mycophenolic acid (MA) inhibits the growth of some pathogenic fungi such as Candida albicans, Cryptococcus neoformans and several species of Trichophyton at low concentrations in vitro. The antibiotic is more effectvie against fungi at slightly acidic pH than neutral pH. When administered to mice through the intraperitoneal, intramuscular and oral routes MA excreted toafewper cent in the urine....
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We examined 233 silage samples and found that molds were present in 206 samples with counts between 1 x 10(3) and 8.9 x 10(7) (mean, 4.7 x 10(6)) CFU/g. Mycophenolic acid, a metabolite of Penicillium roqueforti, was detected by liquid chromatography-mass spectrometry in 74 (32%) of these samples at levels ranging from 20 to 35,000 (mean, 1,400) microg/kg. This compound has well-known immunosupp...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1969
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.22.165